A missile strike by a US drone aircraft hit Pakistan's northwest tribal region near the Afghan border on Wednesday, killing at least four militants, security officials said. The strike took place at 8:00 pm (1500 GMT) in Mizar Madakhel village, some 50 kilometres (31 miles) west of Miranshah, the main town of the tribal North Waziristan district and a known hub of Taliban and Al-Qaeda-linked militants.